Therapeutic Approaches to Counteract Immediate Blood-Mediated Inflammatory Reaction in Islet Transplantation
نویسندگان
چکیده
منابع مشابه
Therapeutic approaches to counteract immediate blood-mediated inflammatory reaction in islet transplantation.
I t is not too common to witness the definition of a key, novel biological phenomenon that profoundly influences both our thinking and our approach to an experimental clinical problem. This has been indeed the case, in the field of islet transplantation, with the description of the immediate bloodmediated inflammatory reaction (IBMIR) by Bennet and Korsgren (1–3), because its impact on transpla...
متن کاملIslet surface heparinization prevents the instant blood-mediated inflammatory reaction in islet transplantation.
OBJECTIVE In clinical islet transplantation, the instant blood-mediated inflammatory reaction (IBMIR) is a major factor contributing to the poor initial engraftment of the islets. This reaction is triggered by tissue factor and monocyte chemoattractant protein (MCP)-1, expressed by the transplanted pancreatic islets when the islets come in contact with blood in the portal vein. All currently id...
متن کاملRegulation of Instant Blood Mediated Inflammatory Reaction (IBMIR) in Pancreatic Islet Xeno-Transplantation: Points for Therapeutic Interventions.
Xeno-transplantation of pancreatic islets represents a promising therapeutic alternative for the treatment of type 1 diabetes mellitus. However, potent innate immune responses induced shortly after the transplantation of donor islets to the recipient, comprising the Instant Blood Mediated Immune Reaction (IBMIR), exert detrimental actions on islet graft function. The coagulation and complement ...
متن کاملDissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation.
BACKGROUND A massive destruction of transplanted tissue occurs immediately following transplantation of pancreatic islets from pig to non-human primates. The detrimental instant blood-mediated inflammatory reaction (IBMIR), triggered by the porcine islets, is a likely explanation for this tissue loss. This reaction may also be responsible for mediating an adaptive immune response in the recipie...
متن کاملDual islet transplantation modeling of the instant blood-mediated inflammatory reaction.
Islet xenotransplantation is a potential treatment for diabetes without the limitations of tissue availability. Although successful experimentally, early islet loss remains substantial and attributed to an instant blood-mediated inflammatory reaction (IBMIR). This syndrome of islet destruction has been incompletely defined and characterization in pig-to-primate models has been hampered by logis...
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ژورنال
عنوان ژورنال: Transplantation
سال: 2006
ISSN: 0041-1337
DOI: 10.1097/01.tp.0000228879.22020.0f